Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808
نویسندگان
چکیده
منابع مشابه
Early clinical PET imaging results with the novel PHF-tau radioligand [F18]-T808.
Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have recently reported early clinical results of a novel PHF-tau targeting PET imaging agent, [F18]-T807. Since then, we have investigated a second novel PHF-tau targeting PET imaging agent, [F18]-T808, with different pharmacokinetic chara...
متن کاملEarly clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807.
Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have developed a novel PHF-tau targeting positron emission tomography imaging agent, [F-18]-T807, which may be useful for imaging Alzheimer's disease and other tauopathies. Here in, we describe the first human brain images with [F-18]-T807.
متن کاملComparison of New Tau PET-Tracer Candidates With [18F]T808 and [18F]T807
Early clinical results of two tau tracers, [(18)F]T808 and [(18)F]T807, have recently been reported. In the present study, the biodistribution, radiometabolite quantification, and competition-binding studies were performed in order to acquire comparative preclinical data as well as to establish the value of T808 and T807 as benchmark compounds for assessment of binding affinities of eight new/o...
متن کاملDevelopments in Tau PET Imaging.
ABSTRACT The presence of neurofibrillary tangles in the brain is a hallmark feature of several neurodegenerative diseases termed "tauopathies," including Alzheimer's disease (AD) and the tau molecular subgroup of frontotemporal lobar degeneration (FTLD-tau). Recently, several positron emission tomography (PET) radiopharmaceuticals targeting abnormal conformations of the tau protein have been de...
متن کاملClinical PET imaging with the C-PET camera.
OBJECTIVE Clinical PET studies require a high-performance and user-friendly PET camera. The C-PET camera uses a simple design and a large field of view for these purposes. METHODS We describe the camera features, daily quality control, and routine clinical study preparation, performance, processing and presentation from the technologist's perspective. RESULTS The C-PET camera is used for wh...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease
سال: 2013
ISSN: 1875-8908,1387-2877
DOI: 10.3233/jad-130098